CAR T-cell Therapy

CAR T-cell Therapy (Chimeric Antigen Receptor T-cell therapy) is a groundbreaking immunotherapy that harnesses the power of the body’s own immune system to fight hematologic cancers such as leukemia, lymphoma, and myeloma. The therapy involves collecting T-cells (a type of white blood cell) from the patient’s blood, genetically modifying them in a laboratory to express a chimeric antigen receptor (CAR) that recognizes cancer-specific antigens, and then reinfusing the modified T-cells back into the patient. This modification enables the T-cells to specifically target and kill cancer cells with greater precision and efficacy. CAR T-cell therapy has shown remarkable success in treating patients with refractory or relapsed blood cancers, especially in conditions like acute lymphoblastic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL), where traditional treatments have failed. For example, in some cases of ALL, CAR T-cells have resulted in complete remission for patients who previously had limited options. Despite its potential, CAR T-cell therapy can cause significant side effects, such as cytokine release syndrome (CRS), a systemic inflammatory response, and neurologic toxicities, which need careful monitoring and management by specialized medical teams.

What is a CAR T-cell Therapy?

CAR T-cell therapy is administered in a highly controlled setting, typically at specialized cancer treatment centers, and requires rigorous follow-up care. The treatment is tailored to each patient’s unique cancer profile, offering a personalized approach that has the potential to be curative. As research progresses, the scope of CAR T-cell therapy is expanding, with ongoing trials exploring its use in other hematologic malignancies and solid tumors, further solidifying its role as a transformative therapy in hematologic oncology.

Dr. Arijit Bishnu and his team use advanced diagnostics, such as genetic testing and molecular profiling, to determine whether targeted therapy is right for a patient. Treatment is then closely monitored and adjusted based on response and tolerance :
Medical History Review: Understanding your symptoms, lifestyle, and medical history to assess any underlying conditions that may be contributing to the menstrual issues.

Treatment of specific blood cancers - Used in conditions such as chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), certain lymphomas, and myeloproliferative neoplasms.

Molecular targeting - Focuses on proteins, genes, or cellular pathways that drive abnormal blood cell growth or survival.

Genetic testing required -Requires molecular diagnostics to identify the presence of targetable mutations or markers.

Fewer side effects than chemotherapy - Typically spares normal cells, leading to lower risk of hair loss, nausea, or widespread immune suppression.

Key advancement in personalized medicine - Allows hematologists to match treatment to each patient’s unique disease profile for optimal outcomes.

Testimonials

Dr Arijit Bishnu is the best haemato- onchologist in Siliguri, with great skills and friendly nature.

★★★★★

- Takhelmayum Sayon Singh

I am deeply grateful to Dr. Arijit Bishnu for his outstanding care during my lymphoma treatment. His expertise and compassionate approach made a challenging time much more manageable. Dr. Bisnu took the time to explain every aspect of my treatment clearly, ensuring I felt informed and supported. His dedication and commitment to my well-being were truly reassuring. I am thankful to have had Dr. Bisnu as my doctor and for the positive impact he has had on my recovery journey.

★★★★★

- Sathi Chowdhury

Dr. Arijit Bishnu is one of the best Hematology and oncologists. He is very knowledgeable , humble and very cooperative at the same time. His advanced treatment measures have helped in my recovery at a much faster pace. Still undergoing treatment to beat cancer, I’m really grateful to Dr. Arijit Bishnu for treating me so well.

★★★★★

- Prabal Roy

A great experience getting an experienced doctor who serves with ethics and takes care a patient minutely.

★★★★★

- Debashish Anjoy

My mother is 84 years old and she is able to take 6 chemos under his treatment. The patient feels safe and secure in his presence. We are really greatful and thankful to him.

★★★★★

- Bijoya Chakraborty

The way Doctor approaches towards the patient with his humble attitude and pays great attention to each & every word of the patient with lots of patience is truly commendable.

★★★★★

- Aritri Sarkar

Superb Doctor…awesome behaviour….best for transplant and blood disorders.

★★★★★

- Amit

One of the best Hematologist in the town. Very knowledgeable and cooperative. Create good bonding with patient and make them fill comfortable.

★★★★★

- Abhishek Sharma

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